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西安交通大學(xué)航天學(xué)院研究論文“Fluid Mechanics in Dentinal Microtubules Provides Mechanistic Insights into the Difference between Hot and Cold Dental Pain”在國際著名學(xué)術(shù)刊物《公共科學(xué)圖書館—綜合》（PLoS ONE）上發(fā)表。

該論文是航天學(xué)院生物醫(yī)學(xué)工程與生物力學(xué)研究中心博士生林敏，在導(dǎo)師盧天健教授和哈佛大學(xué)醫(yī)學(xué)院徐峰博士共同指導(dǎo)下，與能動學(xué)院白博峰教授合作完成，被PLoS ONE主編確認(rèn)為不需要外審就可接收的論文。該項(xiàng)研究得到了國家杰出青年科學(xué)基金及國家外專局/教育部學(xué)科創(chuàng)新引智計(jì)劃項(xiàng)目的共同資助。

冷刺激能快速誘發(fā)短暫的牙痛感（銳痛），而熱刺激則需要延遲一段時(shí)間才能產(chǎn)生持久的疼痛感（鈍痛），這一現(xiàn)象眾所周知，但背后的隱藏的機(jī)理卻始終是個(gè)迷。學(xué)術(shù)界至今無法對冷熱刺激引起的牙疼痛機(jī)理作出令人滿意的定量或是定性解釋。該篇論文作者針對這一難題，提出了交叉學(xué)科的研究方法，利用生物微流體力學(xué)模型模擬冷熱刺激下牙本質(zhì)微管內(nèi)體液的定向流動對牙髓神經(jīng)末梢的剪切力，并提出修正的Hodgkin-Huxley神經(jīng)動力學(xué)模型，模擬在剪切力作用下，位于神經(jīng)末梢傷害性感受器上機(jī)械敏感性離子通道的開放特性以及神經(jīng)元放電信號，并與已有的實(shí)驗(yàn)結(jié)果相吻合。該研究在國際上首次揭示了牙齒冷熱疼痛的區(qū)別機(jī)制，并給出了定量化研究，提出的模型可以預(yù)測傷害性刺激引起牙痛強(qiáng)度，并據(jù)此來評價(jià)、優(yōu)化口腔臨床診療方法，為臨床口腔鎮(zhèn)痛治療提供了理論支持。

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PLoS ONE 6(3): e18068. doi:10.1371/journal.pone.0018068

Fluid Mechanics in Dentinal Microtubules Provides Mechanistic Insights into the Difference between Hot and Cold Dental Pain

Min Lin1, Zheng Yuan Luo2, Bo Feng Bai2, Feng Xu1,3*, Tian Jian Lu1*

1 School of Aerospace, Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, People's Republic of China, 2 State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, People's Republic of China, 3 Department of Medicine, HST-Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Dental thermal pain is a significant health problem in daily life and dentistry. There is a long-standing question regarding the phenomenon that cold stimulation evokes sharper and more shooting pain sensations than hot stimulation. This phenomenon, however, outlives the well-known hydrodynamic theory used to explain dental thermal pain mechanism. Here, we present a mathematical model based on the hypothesis that hot or cold stimulation-induced different directions of dentinal fluid flow and the corresponding odontoblast movements in dentinal microtubules contribute to different dental pain responses. We coupled a computational fluid dynamics model, describing the fluid mechanics in dentinal microtubules, with a modified Hodgkin-Huxley model, describing the discharge behavior of intradental neuron. The simulated results agreed well with existing experimental measurements. We thence demonstrated theoretically that intradental mechano-sensitive nociceptors are not “equally sensitive” to inward (into the pulp) and outward (away from the pulp) fluid flows, providing mechanistic insights into the difference between hot and cold dental pain. The model developed here could enable better diagnosis in endodontics which requires an understanding of pulpal histology, neurology and physiology, as well as their dynamic response to the thermal stimulation used in dental practices.

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