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德國耶拿大學(xué)科研人員最新公布的一項研究結(jié)果表明，攝入微量鋰元素有助于一種線蟲延年益壽。

耶拿大學(xué)的研究者和日本同行在新一期《歐洲營養(yǎng)學(xué)期刊》（European Journal of Nutrition）上報告說，他們聯(lián)合對日本大分縣18個城鎮(zhèn)自來水的鋰含量與當(dāng)?shù)氐乃劳雎首髁讼嚓P(guān)性調(diào)查，結(jié)果發(fā)現(xiàn)在自來水鋰含量較高的城鎮(zhèn)，其人口死亡率明顯較低。

為了驗證這種相關(guān)性，研究人員讓秀麗隱桿線蟲攝入微量鋰元素，其含量水平與日本大分縣低死亡率城鎮(zhèn)的自來水鋰含量相當(dāng)，結(jié)果發(fā)現(xiàn)攝入鋰元素的那些線蟲平均壽命也較高。

據(jù)耶拿大學(xué)人類營養(yǎng)學(xué)教授羅斯托介紹，鋰是一種人們主要通過吃蔬菜和飲用自來水?dāng)z入的生命活動必備元素。耶拿大學(xué)此前曾在實驗中發(fā)現(xiàn)秀麗隱桿線蟲攝入大量鋰元素后壽命明顯延長，但當(dāng)時使用的鋰劑量是自來水中常見鋰含量的1000倍，對人體有毒，所以科研人員此次又通過實驗研究了微量的鋰對秀麗隱桿線蟲壽命的影響。

耶拿大學(xué)的研究者還指出，此前有一些研究發(fā)現(xiàn)，通過自來水較多地攝入鋰元素有助于改善情緒，降低自殺率。但是科研人員迄今尚未完全了解鋰對人體生理的作用機理，雖不排除將來人類通過營養(yǎng)補充劑攝入微量鋰元素的可能性，但為證實其科學(xué)性和安全性還需作進(jìn)一步研究。

推薦原文出處：

European Journal of Nutrition  DOI: 10.1007/s00394-011-0171-x

Low-dose lithium uptake promotes longevity in humans and metazoans

Kim Zarse, Takeshi Terao, Jing Tian, Noboru Iwata, Nobuyoshi Ishii and Michael Ristow

Abstract

Purpose

Lithium is a nutritionally essential trace element predominantly contained in vegetables, plant-derived foods, and drinking water. Environmental lithium exposure and concurrent nutritional intake vary considerably in different regions. We here have analyzed the possibility that low-dose lithium exposure may affect mortality in both metazoans and mammals.

Methods

Based on a large Japanese observational cohort, we have used weighted regression analysis to identify putative effects of tap water-derived lithium uptake on overall mortality. Independently, we have exposed Caenorhabditis elegans, a small roundworm commonly used for anti-aging studies, to comparable concentrations of lithium, and have quantified mortality during this intervention.

Results

In humans, we find here an inverse correlation between drinking water lithium concentrations and all-cause mortality in 18 neighboring Japanese municipalities with a total of 1,206,174 individuals (β = ?0.661, p = 0.003). Consistently, we find that exposure to a comparably low concentration of lithium chloride extends life span of C. elegans (p = 0.047).

Conclusions

Taken together, these findings indicate that long-term low-dose exposure to lithium may exert anti-aging capabilities and unambiguously decreases mortality in evolutionary distinct species.

Keywords  Trace elements – Lithium – Mortality – Longevity – Human –  C. elegans

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